Can You Take Spironolactone and St. John's Wort Together?
No documented interaction was identified between spironolactone and St. John's Wort in the sources reviewed.
See the full Spironolactone page and St. John's Wort page for other reviewed interactions and reference information.
What the interaction means
Spironolactone's FDA label's full Drug Interactions section does not mention St. John's Wort. NCCIH's St. John's Wort page does not mention spironolactone.
No documented interaction between Spironolactone and St. John's Wort was identified in the authoritative sources reviewed. This is not a guarantee that no interaction exists for every dose, formulation, or individual -- it means the sources checked did not document one.
Practical context
Both Spironolactone's and St. John's Wort's own current authoritative sources were checked directly, full text, in both directions.
What the sources say
Last reviewed 2026-08-23
Medical information disclaimer: this information is general and educational. It does not diagnose conditions, prescribe treatment, or determine whether a combination is safe for you personally. Follow your prescription label and ask a pharmacist or clinician before starting, stopping, or combining products. Full disclaimer.
Related guides
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- St. John's Wort and Vitamin EInsufficient evidence
- St. John's Wort and Vitamin KInsufficient evidence
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- St. John's Wort and DoxycyclineInsufficient evidence
- St. John's Wort and CopperInsufficient evidence
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- St. John's Wort and Vitamin CInsufficient evidence
- St. John's Wort and CalciumInsufficient evidence
- St. John's Wort and IronInsufficient evidence
- St. John's Wort and MagnesiumInsufficient evidence
- St. John's Wort and Vitamin B12Insufficient evidence
- St. John's Wort and AshwagandhaInsufficient evidence
- St. John's Wort and Omega-3 / Fish OilInsufficient evidence
- St. John's Wort and ZincInsufficient evidence
- St. John's Wort and LisinoprilInsufficient evidence
- St. John's Wort and CoQ10 (Coenzyme Q10)Insufficient evidence
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- St. John's Wort and MelatoninInsufficient evidence
- St. John's Wort and ProbioticsInsufficient evidence
- St. John's Wort and AspirinInsufficient evidence
- St. John's Wort and AmlodipineInsufficient evidence
- St. John's Wort and LevothyroxineInsufficient evidence
- St. John's Wort and IbuprofenInsufficient evidence
- St. John's Wort and TurmericInsufficient evidence
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