Can You Take Ashwagandha and St. John's Wort Together?
No documented interaction was identified between ashwagandha and St. John's Wort in the sources reviewed.
See the full Ashwagandha page and St. John's Wort page for other reviewed interactions and reference information.
What the interaction means
NCCIH's ashwagandha fact sheet names six medication classes it may interact with (diabetes medicines, high blood pressure medicines, immunosuppressants, sedatives, anticonvulsants, and thyroid hormone medications) -- herbal supplements generally, and St. John's Wort specifically, are not among them, and NCCIH's St. John's Wort page does not mention ashwagandha.
No documented interaction between Ashwagandha and St. John's Wort was identified in the authoritative sources reviewed. This is not a guarantee that no interaction exists for every dose, formulation, or individual -- it means the sources checked did not document one.
Practical context
Ashwagandha's NCCIH fact sheet and NCCIH's St. John's Wort page were checked directly, full text, in both directions. NCCIH's list of six interacting medication classes for ashwagandha does not include other herbal supplements.
What the sources say
Last reviewed 2026-08-25
Medical information disclaimer: this information is general and educational. It does not diagnose conditions, prescribe treatment, or determine whether a combination is safe for you personally. Follow your prescription label and ask a pharmacist or clinician before starting, stopping, or combining products. Full disclaimer.
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