Can You Take Copper and St. John's Wort Together?
Copper's own NIH fact sheet states it is not known to interact with any medications, and no interaction with St. John's Wort is documented.
What the interaction means
The NIH Office of Dietary Supplements' copper fact sheet states plainly: "Copper is not known to interact with any medications." NCCIH's St. John's Wort page does not mention copper.
No documented interaction was identified in the authoritative sources reviewed. This is not a guarantee that no interaction exists for every dose, formulation, or individual -- it means the sources checked did not document one.
Practical context
Copper's own source gives an explicit negative statement, which is why this is rated higher evidence quality.
What the sources say
Last reviewed 2026-08-23
Medical information disclaimer: this information is general and educational. It does not diagnose conditions, prescribe treatment, or determine whether a combination is safe for you personally. Follow your prescription label and ask a pharmacist or clinician before starting, stopping, or combining products. Full disclaimer.
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- St. John's Wort and CiprofloxacinInsufficient evidence
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- St. John's Wort and Vitamin B12Insufficient evidence
- St. John's Wort and Vitamin KInsufficient evidence
- St. John's Wort and LevothyroxineInsufficient evidence
- St. John's Wort and PotassiumInsufficient evidence
- St. John's Wort and SpironolactoneInsufficient evidence
- St. John's Wort and AtorvastatinInsufficient evidence
- St. John's Wort and ZincInsufficient evidence
- St. John's Wort and CoQ10 (Coenzyme Q10)Insufficient evidence
- St. John's Wort and OmeprazoleInsufficient evidence
- St. John's Wort and MetforminInsufficient evidence
- St. John's Wort and LisinoprilInsufficient evidence
- St. John's Wort and DoxycyclineInsufficient evidence
- St. John's Wort and CaffeineInsufficient evidence
- St. John's Wort and Vitamin DInsufficient evidence
- St. John's Wort and ProbioticsInsufficient evidence
- St. John's Wort and CreatineInsufficient evidence
- St. John's Wort and MelatoninInsufficient evidence
- St. John's Wort and TurmericInsufficient evidence