Can You Take Copper and Vitamin B12 Together?
Copper's own NIH fact sheet states it is not known to interact with any medications, and no interaction with vitamin B12 is documented.
What the interaction means
The NIH Office of Dietary Supplements' copper fact sheet states plainly: "Copper is not known to interact with any medications." Vitamin B12's own fact sheet does not mention copper.
No documented interaction was identified in the authoritative sources reviewed. This is not a guarantee that no interaction exists for every dose, formulation, or individual -- it means the sources checked did not document one.
Practical context
Copper's own source gives an explicit negative statement, which is why this is rated higher evidence quality.
What the sources say
Last reviewed 2026-08-23
Medical information disclaimer: this information is general and educational. It does not diagnose conditions, prescribe treatment, or determine whether a combination is safe for you personally. Follow your prescription label and ask a pharmacist or clinician before starting, stopping, or combining products. Full disclaimer.
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- Vitamin B12 and St. John's WortInsufficient evidence
- Vitamin B12 and ZincInsufficient evidence
- Vitamin B12 and CoQ10 (Coenzyme Q10)Insufficient evidence
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- Vitamin B12 and DoxycyclineInsufficient evidence
- Vitamin B12 and ProbioticsInsufficient evidence
- Vitamin B12 and AtorvastatinInsufficient evidence
- Vitamin B12 and CreatineInsufficient evidence
- Vitamin B12 and CaffeineInsufficient evidence
- Vitamin B12 and SertralineInsufficient evidence
- Vitamin B12 and Vitamin DInsufficient evidence
- Vitamin B12 and Vitamin KInsufficient evidence
- Vitamin B12 and LevothyroxineInsufficient evidence
- Vitamin B12 and PotassiumInsufficient evidence
- Vitamin B12 and SpironolactoneInsufficient evidence