Can I Take These?

Can You Take Caffeine and Vitamin B12 Together?

No documented interaction was identified between vitamin B12 and caffeine in the sources reviewed.

No documented interaction identifiedEvidence: Moderate

See the full Caffeine page and Vitamin B12 page for other reviewed interactions and reference information.

What the interaction means

The NIH ODS vitamin B12 fact sheet's interactions section names only gastric acid inhibitors and metformin -- caffeine is not named. MedlinePlus's caffeine page does not mention vitamin B12.

No documented interaction between Caffeine and Vitamin B12 was identified in the authoritative sources reviewed. This is not a guarantee that no interaction exists for every dose, formulation, or individual -- it means the sources checked did not document one.

Practical context

Both substances' own current authoritative sources were checked directly, in both directions.

What the sources say

Vitamin B12 — Consumer — NIH Office of Dietary SupplementsCaffeine — MedlinePlus, U.S. National Library of Medicine

Last reviewed 2026-08-23

Medical information disclaimer: this information is general and educational. It does not diagnose conditions, prescribe treatment, or determine whether a combination is safe for you personally. Follow your prescription label and ask a pharmacist or clinician before starting, stopping, or combining products. Full disclaimer.

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