Can I Take These?

Can You Take Caffeine and Vitamin B12 Together?

No documented interaction was identified between vitamin B12 and caffeine in the sources reviewed.

No documented interaction identifiedEvidence: Moderate

What the interaction means

The NIH ODS vitamin B12 fact sheet's interactions section names only gastric acid inhibitors and metformin -- caffeine is not named. MedlinePlus's caffeine page does not mention vitamin B12.

No documented interaction was identified in the authoritative sources reviewed. This is not a guarantee that no interaction exists for every dose, formulation, or individual -- it means the sources checked did not document one.

Practical context

Both substances' own current authoritative sources were checked directly, in both directions.

What the sources say

Vitamin B12 — Consumer — NIH Office of Dietary SupplementsCaffeine — MedlinePlus, U.S. National Library of Medicine

Last reviewed 2026-08-23

Medical information disclaimer: this information is general and educational. It does not diagnose conditions, prescribe treatment, or determine whether a combination is safe for you personally. Follow your prescription label and ask a pharmacist or clinician before starting, stopping, or combining products. Full disclaimer.

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