Can I Take These?

Can You Take Sertraline and Vitamin B12 Together?

No documented interaction was identified between sertraline and vitamin B12 in the sources reviewed.

No documented interaction identifiedEvidence: Moderate

See the full Sertraline page and Vitamin B12 page for other reviewed interactions and reference information.

What the interaction means

Sertraline's FDA label does not mention vitamin B12 anywhere in its actual prose content. The NIH ODS vitamin B12 fact sheet does not mention sertraline.

No documented interaction between Sertraline and Vitamin B12 was identified in the authoritative sources reviewed. This is not a guarantee that no interaction exists for every dose, formulation, or individual -- it means the sources checked did not document one.

Practical context

Both substances' own current authoritative sources were checked directly, full text, in both directions -- sertraline's label was checked with script-embedded content excluded, ruling out the generic taxonomy-dropdown false-positive pattern seen elsewhere in this catalog.

What the sources say

Vitamin B12 — Consumer — NIH Office of Dietary SupplementsSertraline Hydrochloride Tablets — FDA Prescribing Information — Via DailyMed, U.S. National Library of Medicine

Last reviewed 2026-08-23

Medical information disclaimer: this information is general and educational. It does not diagnose conditions, prescribe treatment, or determine whether a combination is safe for you personally. Follow your prescription label and ask a pharmacist or clinician before starting, stopping, or combining products. Full disclaimer.

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