Can I Take These?

Can You Take Losartan and Sertraline Together?

No documented interaction was identified between losartan and sertraline in the sources reviewed.

No documented interaction identifiedEvidence: Moderate

See the full Losartan page and Sertraline page for other reviewed interactions and reference information.

What the interaction means

Losartan's FDA label documents four drug-interaction categories -- potassium-raising drugs, lithium, NSAIDs, and dual RAS blockade with other ARBs/ACE inhibitors -- and sertraline or SSRIs are not among them. Sertraline's own FDA label does not mention losartan, ARBs, or angiotensin.

No documented interaction between Losartan and Sertraline was identified in the authoritative sources reviewed. This is not a guarantee that no interaction exists for every dose, formulation, or individual -- it means the sources checked did not document one.

Practical context

Losartan's FDA label and sertraline's FDA label were checked directly, full text, in both directions. Losartan's own named interaction categories do not include SSRIs or other antidepressants.

What the sources say

Sertraline Hydrochloride Tablets — FDA Prescribing Information — Via DailyMed, U.S. National Library of MedicineLosartan Potassium Tablets — FDA Prescribing Information — Bryant Ranch Prepack (via DailyMed, U.S. National Library of Medicine)

Last reviewed 2026-08-25

Medical information disclaimer: this information is general and educational. It does not diagnose conditions, prescribe treatment, or determine whether a combination is safe for you personally. Follow your prescription label and ask a pharmacist or clinician before starting, stopping, or combining products. Full disclaimer.

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