Can I Take These?

Can You Take Aspirin and Losartan Together?

Losartan's MedlinePlus guidance names aspirin directly as a nonprescription product that may interact.

MonitorEvidence: Moderate

See the full Aspirin page and Losartan page for other reviewed interactions and reference information.

What the interaction means

Losartan's MedlinePlus consumer page states: "the following nonprescription products may interact with losartan: aspirin and nonsteroidal anti-inflammatory drugs (NSAIDS) such as ibuprofen (Advil, Motrin, others) and naproxen (Aleve)," instructing patients not to start these without discussing with their healthcare provider. Losartan's FDA prescribing information, Section 7.3, separately warns that NSAIDs, including selective COX-2 inhibitors, may cause renal function deterioration and blunt losartan's antihypertensive effect when coadministered with angiotensin receptor blockers -- aspirin is chemically an NSAID, though that FDA section does not name aspirin specifically the way it names losartan.

Why it may happen

At anti-inflammatory doses, NSAIDs including aspirin inhibit renal prostaglandin synthesis, which can reduce glomerular filtration and blunt the blood-pressure-lowering effect of angiotensin receptor blockers like losartan. Low-dose antiplatelet aspirin has a less pronounced effect on renal prostaglandins than anti-inflammatory dosing, a distinction not addressed in the sources reviewed.

Practical context

Losartan's own consumer-facing guidance flags aspirin by name as something to discuss with a doctor before combining, without distinguishing low-dose (cardioprotective) aspirin from higher, anti-inflammatory doses. Anyone on losartan taking aspirin regularly, at any dose, should mention it to their prescriber.

What the sources say

Losartan Potassium Tablets — FDA Prescribing Information — Granules Pharmaceuticals, Inc. (via DailyMed, U.S. National Library of Medicine)Losartan — MedlinePlus, U.S. National Library of Medicine

Last reviewed 2026-08-24

Medical information disclaimer: this information is general and educational. It does not diagnose conditions, prescribe treatment, or determine whether a combination is safe for you personally. Follow your prescription label and ask a pharmacist or clinician before starting, stopping, or combining products. Full disclaimer.

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