Can I Take These?

Can You Take Aspirin and Warfarin Together?

Aspirin is named directly on warfarin's FDA label as an antiplatelet agent that increases bleeding risk, with a specific combined-therapy regimen described for certain patients.

Use cautionEvidence: High

See the full Aspirin page and Warfarin page for other reviewed interactions and reference information.

What the interaction means

Warfarin's FDA prescribing information lists aspirin by name in "Table 3: Drugs that Can Increase the Risk of Bleeding," under Antiplatelet Agents: "aspirin, cilostazol, clopidogrel, dipyridamole, prasugrel, ticlopidine." Its Patient Counseling Information instructs patients to "Not take or discontinue any other drug, including salicylates (e.g., aspirin and topical analgesics)... except on advice of your physician." Aspirin's own DURLAZA label corroborates this from the aspirin side: "Anticoagulant and antiplatelets: Increased risk of bleeding."

Why it may happen

Aspirin inhibits platelet aggregation (an antiplatelet effect), which adds to warfarin's anticoagulant effect on the clotting cascade, increasing overall bleeding risk when the two are combined.

Practical context

Warfarin's label describes a specific combined regimen used clinically: "combined moderate-intensity (INR, 2.0 to 3.0) warfarin plus low-dose aspirin (≤100 mg/day) for at least 3 months after the MI is recommended" in certain post-myocardial-infarction patients, and cites the WARIS II trial comparing aspirin alone, warfarin alone, and combined therapy. Combined use should be directed and monitored by the prescriber managing anticoagulation, not self-initiated.

What the sources say

Warfarin Sodium Tablets — FDA Prescribing Information — Via DailyMed, U.S. National Library of MedicineDURLAZA (Aspirin) Extended-Release Capsules — FDA Prescribing Information — New Haven Pharmaceuticals, Inc. (via DailyMed, U.S. National Library of Medicine)Bayer Low Dose Aspirin — OTC Drug Facts Label — Bayer HealthCare LLC (via DailyMed, U.S. National Library of Medicine)

Last reviewed 2026-08-24

Medical information disclaimer: this information is general and educational. It does not diagnose conditions, prescribe treatment, or determine whether a combination is safe for you personally. Follow your prescription label and ask a pharmacist or clinician before starting, stopping, or combining products. Full disclaimer.

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