Can I Take These?

Can You Take Vitamin E and Warfarin Together?

Vitamin E's own NIH fact sheets specifically name warfarin as a bleeding-risk interaction at higher supplemental doses.

MonitorEvidence: Moderate

See the full Vitamin E page and Warfarin page for other reviewed interactions and reference information.

What the interaction means

The NIH ODS Health Professional fact sheet for vitamin E states: "Vitamin E can inhibit platelet aggregation and antagonize vitamin K-dependent clotting factors," and that taking large doses along with anticoagulant or antiplatelet medications "such as warfarin (Coumadin)" can increase bleeding risk, "especially in conjunction with low vitamin K intake." The Consumer fact sheet states this more plainly: "Vitamin E can increase the risk of bleeding in people taking anticoagulant or antiplatelet medicines, such as warfarin (Coumadin)." Warfarin's own FDA label does not name vitamin E, so this finding is documented from the vitamin E side.

Why it may happen

Per the ODS fact sheet, vitamin E "is thought to inhibit the oxidation of reduced vitamin K and interfere with the functions of vitamin K-dependent clotting factors," effects described as dose-dependent and more pronounced with preexisting low vitamin K status.

Practical context

ODS notes the amounts needed to produce clinically significant effects are unknown but "probably exceed 400 IU/day," and recommends "close clinical and laboratory observation for hematologic complications" when vitamin E supplementation above 400 units/day is started in someone already stabilized on anticoagulant or antiplatelet therapy. Anyone on warfarin should discuss vitamin E supplement use, especially at doses above typical multivitamin levels, with the clinician managing their anticoagulation.

What the sources say

Warfarin Sodium Tablets — FDA Prescribing Information — Amneal Pharmaceuticals LLC (via DailyMed, U.S. National Library of Medicine)Vitamin E - Consumer — NIH Office of Dietary SupplementsVitamin E - Health Professional Fact Sheet — NIH Office of Dietary SupplementsVitamin E — MedlinePlus, U.S. National Library of Medicine

Last reviewed 2026-08-24

Medical information disclaimer: this information is general and educational. It does not diagnose conditions, prescribe treatment, or determine whether a combination is safe for you personally. Follow your prescription label and ask a pharmacist or clinician before starting, stopping, or combining products. Full disclaimer.

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