Vitamin E
Vitamin E is a fat-soluble antioxidant vitamin obtained from food and dietary supplements, most commonly used in supplement form as alpha-tocopherol.
What it is
Vitamin E is a fat-soluble nutrient with antioxidant properties, found naturally in vegetable oils, nuts, seeds, and green leafy vegetables, and available as a dietary supplement (typically alpha-tocopherol). According to the NIH Office of Dietary Supplements, most Americans' diets provide less than the RDA, but frank deficiency is rare in healthy people. At high supplemental doses, vitamin E can inhibit platelet aggregation and antagonize vitamin K-dependent clotting factors, which is the basis for its documented interactions with anticoagulant/antiplatelet medications and with vitamin K itself.
Food and timing considerations
Vitamin E is fat-soluble and is generally better absorbed when taken with a meal containing some fat, per general fat-soluble-vitamin guidance in the sources reviewed.
Known interaction categories
- Insufficient evidence
- Monitor
- Use caution
Published interaction pages on this site
- Vitamin E and OmeprazoleInsufficient evidence
- Vitamin E and SertralineInsufficient evidence
- Vitamin E and Vitamin B12Insufficient evidence
- Vitamin E and SpironolactoneInsufficient evidence
- Vitamin E and St. John's WortInsufficient evidence
- Vitamin E and TurmericInsufficient evidence
- Vitamin E and CalciumInsufficient evidence
- Vitamin E and CiprofloxacinInsufficient evidence
- Vitamin E and Vitamin KMonitor
- Vitamin E and AtorvastatinInsufficient evidence
- Vitamin E and CaffeineInsufficient evidence
- Vitamin E and CopperInsufficient evidence
- Vitamin E and CoQ10 (Coenzyme Q10)Insufficient evidence
- Vitamin E and CreatineInsufficient evidence
- Vitamin E and DoxycyclineInsufficient evidence
- Vitamin E and IronInsufficient evidence
- Vitamin E and LevothyroxineInsufficient evidence
- Vitamin E and LisinoprilInsufficient evidence
- Vitamin E and MagnesiumInsufficient evidence
- Vitamin E and MetforminInsufficient evidence
- Vitamin E and MelatoninInsufficient evidence
- Vitamin E and ProbioticsInsufficient evidence
- Vitamin E and Vitamin CMonitor
- Vitamin E and Omega-3 / Fish OilInsufficient evidence
- Vitamin E and AshwagandhaInsufficient evidence
- Vitamin E and Folate / Folic AcidInsufficient evidence
- Vitamin E and LosartanInsufficient evidence
- Vitamin E and AmlodipineInsufficient evidence
- Vitamin E and AspirinUse caution
- Vitamin E and IbuprofenInsufficient evidence
- Vitamin E and EscitalopramInsufficient evidence
- Vitamin E and PotassiumInsufficient evidence
- Vitamin E and WarfarinMonitor
- Vitamin E and Vitamin DInsufficient evidence
- Vitamin E and ZincInsufficient evidence
Related guides
Sources
Last reviewed 2026-08-24
Medical information disclaimer: this information is general and educational. It does not diagnose conditions, prescribe treatment, or determine whether a combination is safe for you personally. Follow your prescription label and ask a pharmacist or clinician before starting, stopping, or combining products. Full disclaimer.