Can I Take These?

Can You Take Omega-3 / Fish Oil and Vitamin E Together?

No documented interaction was identified between omega-3 and vitamin E in the sources reviewed, though both carry separate, independently documented bleeding-risk cautions with anticoagulants.

No documented interaction identifiedEvidence: Moderate

See the full Omega-3 / Fish Oil page and Vitamin E page for other reviewed interactions and reference information.

What the interaction means

Omega-3's own NIH ODS fact sheet's Interactions with Medications section names only warfarin/anticoagulants, and does not mention vitamin E or tocopherol anywhere. Vitamin E's own NIH ODS fact sheet does not mention omega-3, fish oil, EPA, or DHA anywhere, including in its own warfarin-interaction discussion. The two substances do appear together in the AREDS2 eye-health trial, which added omega-3 (350 mg DHA + 650 mg EPA) directly to the AREDS antioxidant formula containing 400 IU vitamin E; per omega-3's own fact sheet, "the results showed that EPA and DHA did not provide any additional benefits after a median follow-up of 5 years" -- a null efficacy result for eye disease, not a description of an interaction between the two supplements.

No documented interaction was identified in the authoritative sources reviewed. This is not a guarantee that no interaction exists for every dose, formulation, or individual -- it means the sources checked did not document one.

Practical context

Worth noting transparently: omega-3 and vitamin E each carry their own separately documented bleeding-risk caution when combined with anticoagulant medications like warfarin, but via different mechanisms -- omega-3 through antiplatelet effects at high doses, and vitamin E through antagonizing vitamin K-dependent clotting factors (the same mechanism already documented for vitamin E and vitamin K elsewhere in this catalog). Neither fact sheet describes an additive effect between omega-3 and vitamin E specifically when taken together, so this is not recorded as a documented interaction between the two -- but someone already on an anticoagulant should be aware that both supplements independently carry their own bleeding-risk considerations.

What the sources say

Omega-3 Fatty Acids - Health Professional Fact Sheet — NIH Office of Dietary SupplementsVitamin E - Health Professional Fact Sheet — NIH Office of Dietary Supplements

Last reviewed 2026-08-24

Medical information disclaimer: this information is general and educational. It does not diagnose conditions, prescribe treatment, or determine whether a combination is safe for you personally. Follow your prescription label and ask a pharmacist or clinician before starting, stopping, or combining products. Full disclaimer.

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