Can I Take These?

Can You Take Omega-3 / Fish Oil and Vitamin C Together?

No documented interaction was identified between vitamin C and omega-3 in the sources reviewed, though both were combined in the AREDS2 eye-health trial.

No documented interaction identifiedEvidence: Moderate

See the full Omega-3 / Fish Oil page and Vitamin C page for other reviewed interactions and reference information.

What the interaction means

Vitamin C's own NIH ODS fact sheet names only radiation therapy, chemotherapeutic agents, and statins as medication-interaction concerns, and does not mention omega-3, fish oil, EPA, or DHA anywhere. Omega-3's own NIH ODS fact sheet names only warfarin/anticoagulants as a documented medication interaction, and does not mention vitamin C or ascorbic acid as an interacting substance. The two do appear together in the AREDS2 clinical trial: researchers added 350 mg DHA and 650 mg EPA directly to the original AREDS antioxidant formula, which contains 500 mg vitamin C (along with vitamin E, zinc, copper, and beta-carotene), to see whether it improved eye-disease outcomes.

No documented interaction was identified in the authoritative sources reviewed. This is not a guarantee that no interaction exists for every dose, formulation, or individual -- it means the sources checked did not document one.

Practical context

AREDS2's finding was a null efficacy result, not a safety concern: "the results showed that EPA and DHA did not provide any additional benefits after a median follow-up of 5 years" for slowing age-related macular degeneration progression. This is reassuring co-administration context -- both substances were combined in a large, multi-year randomized trial population without a safety signal being reported -- but it is not a description of a pharmacological interaction between vitamin C and omega-3 themselves.

What the sources say

Omega-3 Fatty Acids - Health Professional Fact Sheet — NIH Office of Dietary SupplementsVitamin C — Health Professional Fact Sheet — NIH Office of Dietary Supplements

Last reviewed 2026-08-24

Medical information disclaimer: this information is general and educational. It does not diagnose conditions, prescribe treatment, or determine whether a combination is safe for you personally. Follow your prescription label and ask a pharmacist or clinician before starting, stopping, or combining products. Full disclaimer.

Related interactions