Can I Take These?

Can You Take Atorvastatin and Omega-3 / Fish Oil Together?

A pharmacokinetic study found atorvastatin and omega-3 measurably affect each other's blood levels, but the authors concluded the change is not clinically significant.

InformationalEvidence: Moderate

See the full Atorvastatin page and Omega-3 / Fish Oil page for other reviewed interactions and reference information.

What the interaction means

A 2022 crossover pharmacokinetic study in healthy volunteers found that co-administering atorvastatin and omega-3 changed each other's blood levels: atorvastatin's active metabolite 2-OH-atorvastatin increased by about 18.5%, while omega-3 absorption (DHA and EPA) decreased substantially. The study states: "The 90% CIs for most primary endpoints were outside the range of typical bioequivalence, indicating a pharmacokinetic interaction between atorvastatin and omega-3."

Why it may happen

Not fully characterized in the source beyond describing it as a pharmacokinetic (absorption/metabolism) interaction rather than a direct pharmacodynamic one.

Practical context

The study authors explicitly conclude this is not a safety concern: "the safety was similar between atorvastatin or omega-3 single administration and atorvastatin + omega-3 co-administration," and "the change in the efficacy of atorvastatin after co-administration with omega-3 is not expected to be clinically significant." Both were "well tolerated without serious myopathy." This is a single pharmacokinetic study in healthy volunteers, not a large outcomes trial, and NIH ODS's own interactions section does not separately flag atorvastatin or statins as an omega-3 interaction.

What the sources say

Pharmacokinetic Interaction between Atorvastatin and Omega-3 Fatty Acid in Healthy Volunteers — Pharmaceuticals (Basel), MDPI, via PubMed Central

Last reviewed 2026-08-24

Medical information disclaimer: this information is general and educational. It does not diagnose conditions, prescribe treatment, or determine whether a combination is safe for you personally. Follow your prescription label and ask a pharmacist or clinician before starting, stopping, or combining products. Full disclaimer.

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