Can I Take These?

Can You Take Atorvastatin and Sertraline Together?

No documented interaction was identified between atorvastatin and sertraline in the sources reviewed.

No documented interaction identifiedEvidence: Moderate

See the full Atorvastatin page and Sertraline page for other reviewed interactions and reference information.

What the interaction means

Atorvastatin's FDA label's drug-interaction section is mostly CYP3A4-mediated (cyclosporine, gemfibrozil, several CYP3A4 inhibitors, rifampin) -- sertraline is not among them. Sertraline's own FDA label does not mention atorvastatin or statins.

No documented interaction between Atorvastatin and Sertraline was identified in the authoritative sources reviewed. This is not a guarantee that no interaction exists for every dose, formulation, or individual -- it means the sources checked did not document one.

Practical context

Atorvastatin's and sertraline's FDA labels were checked directly, full text, in both directions. Sertraline is not a CYP3A4-mediated concern and is not named.

What the sources say

Sertraline Hydrochloride Tablets — FDA Prescribing Information — Via DailyMed, U.S. National Library of MedicineAtorvastatin Calcium Tablet — FDA Prescribing Information — Zydus Pharmaceuticals USA Inc. (via DailyMed, U.S. National Library of Medicine)

Last reviewed 2026-08-25

Medical information disclaimer: this information is general and educational. It does not diagnose conditions, prescribe treatment, or determine whether a combination is safe for you personally. Follow your prescription label and ask a pharmacist or clinician before starting, stopping, or combining products. Full disclaimer.

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