Can I Take These?

Can You Take Caffeine and Sertraline Together?

No documented interaction was identified between caffeine and sertraline in the sources reviewed.

No documented interaction identifiedEvidence: Moderate

See the full Caffeine page and Sertraline page for other reviewed interactions and reference information.

What the interaction means

Sertraline's FDA label names an extensive drug-interaction list (MAOIs, pimozide, other serotonergic agents, anticoagulants/antiplatelets, CYP2D6 substrates, phenytoin, cimetidine, digoxin, and more) -- caffeine is not among them. MedlinePlus's caffeine page does not mention sertraline.

No documented interaction between Caffeine and Sertraline was identified in the authoritative sources reviewed. This is not a guarantee that no interaction exists for every dose, formulation, or individual -- it means the sources checked did not document one.

Practical context

Sertraline's FDA label and MedlinePlus's caffeine page were checked directly, full text, in both directions. Caffeine is not a serotonergic, CYP2D6-mediated, or bleeding-risk concern, and is not named.

What the sources say

Sertraline Hydrochloride Tablets — FDA Prescribing Information — Via DailyMed, U.S. National Library of MedicineCaffeine — MedlinePlus, U.S. National Library of Medicine

Last reviewed 2026-08-25

Medical information disclaimer: this information is general and educational. It does not diagnose conditions, prescribe treatment, or determine whether a combination is safe for you personally. Follow your prescription label and ask a pharmacist or clinician before starting, stopping, or combining products. Full disclaimer.

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