Can I Take These?

Can You Take Caffeine and Melatonin Together?

No documented interaction was identified between melatonin and caffeine in the sources reviewed.

No documented interaction identifiedEvidence: Moderate

What the interaction means

NCCIH's melatonin page does not mention caffeine. MedlinePlus's caffeine page does not mention melatonin.

No documented interaction was identified in the authoritative sources reviewed. This is not a guarantee that no interaction exists for every dose, formulation, or individual -- it means the sources checked did not document one.

Practical context

Both substances' own current authoritative sources were checked directly, full text, in both directions.

What the sources say

Caffeine — MedlinePlus, U.S. National Library of MedicineMelatonin: What You Need To Know — National Center for Complementary and Integrative Health (NIH)

Last reviewed 2026-08-23

Medical information disclaimer: this information is general and educational. It does not diagnose conditions, prescribe treatment, or determine whether a combination is safe for you personally. Follow your prescription label and ask a pharmacist or clinician before starting, stopping, or combining products. Full disclaimer.

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