Can I Take These?

Can You Take Doxycycline and Melatonin Together?

No documented interaction was identified between doxycycline and melatonin in the sources reviewed.

No documented interaction identifiedEvidence: Moderate

See the full Doxycycline page and Melatonin page for other reviewed interactions and reference information.

What the interaction means

Doxycycline's FDA label's only "melatonin" hit is inside its generic pharmacologic-class taxonomy dropdown, not a prose interaction statement. NCCIH's melatonin page does not mention doxycycline.

No documented interaction between Doxycycline and Melatonin was identified in the authoritative sources reviewed. This is not a guarantee that no interaction exists for every dose, formulation, or individual -- it means the sources checked did not document one.

Practical context

Both Doxycycline's and Melatonin's own current authoritative sources were checked directly, full text, in both directions; the taxonomy-list mention was deliberately not treated as a real interaction claim.

What the sources say

Doxycycline Hyclate — FDA Prescribing Information — Sun Pharmaceutical Industries, Inc. (via DailyMed, U.S. National Library of Medicine)Melatonin: What You Need To Know — National Center for Complementary and Integrative Health (NIH)

Last reviewed 2026-08-23

Medical information disclaimer: this information is general and educational. It does not diagnose conditions, prescribe treatment, or determine whether a combination is safe for you personally. Follow your prescription label and ask a pharmacist or clinician before starting, stopping, or combining products. Full disclaimer.

Related guides

Related interactions