Can I Take These?

Can You Take Doxycycline and Metformin Together?

No documented interaction was identified between doxycycline and metformin in the sources reviewed.

No documented interaction identifiedEvidence: Moderate

See the full Doxycycline page and Metformin page for other reviewed interactions and reference information.

What the interaction means

Doxycycline's FDA label does not mention metformin. Metformin's own FDA label does not mention doxycycline.

No documented interaction between Doxycycline and Metformin was identified in the authoritative sources reviewed. This is not a guarantee that no interaction exists for every dose, formulation, or individual -- it means the sources checked did not document one.

Practical context

Both substances' own current FDA labels were checked directly, in both directions.

What the sources say

Doxycycline Hyclate — FDA Prescribing Information — Sun Pharmaceutical Industries, Inc. (via DailyMed, U.S. National Library of Medicine)Metformin Hydrochloride Tablets, USP — FDA Prescribing Information — Granules Pharmaceuticals Inc. (via DailyMed, U.S. National Library of Medicine)

Last reviewed 2026-08-23

Medical information disclaimer: this information is general and educational. It does not diagnose conditions, prescribe treatment, or determine whether a combination is safe for you personally. Follow your prescription label and ask a pharmacist or clinician before starting, stopping, or combining products. Full disclaimer.

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