Can I Take These?

Can You Take Melatonin and Metformin Together?

No documented interaction was identified between metformin and melatonin in the sources reviewed.

No documented interaction identifiedEvidence: Moderate

See the full Melatonin page and Metformin page for other reviewed interactions and reference information.

What the interaction means

Metformin's FDA label names ~19 drugs/classes affecting glycemic control or lactic-acidosis risk -- melatonin is not among them. NCCIH's melatonin page names exactly two classes needing medical supervision -- epilepsy and blood thinner medications -- and metformin fits neither.

No documented interaction between Melatonin and Metformin was identified in the authoritative sources reviewed. This is not a guarantee that no interaction exists for every dose, formulation, or individual -- it means the sources checked did not document one.

Practical context

Metformin's FDA label and NCCIH's melatonin page were checked directly, full text, in both directions. Metformin is not an anticoagulant/antiplatelet drug or an epilepsy medication, and melatonin is not among metformin's named glycemic-control concerns.

What the sources say

Metformin Hydrochloride Tablets, USP — FDA Prescribing Information — Granules Pharmaceuticals Inc. (via DailyMed, U.S. National Library of Medicine)Melatonin: What You Need To Know — National Center for Complementary and Integrative Health (NIH)

Last reviewed 2026-08-25

Medical information disclaimer: this information is general and educational. It does not diagnose conditions, prescribe treatment, or determine whether a combination is safe for you personally. Follow your prescription label and ask a pharmacist or clinician before starting, stopping, or combining products. Full disclaimer.

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