Can I Take These?

Can You Take Melatonin and Spironolactone Together?

No documented interaction was identified between melatonin and spironolactone in the sources reviewed.

No documented interaction identifiedEvidence: Moderate

See the full Melatonin page and Spironolactone page for other reviewed interactions and reference information.

What the interaction means

Spironolactone's FDA label's only "melatonin" hit is "MELATONIN RECEPTOR AGONIST" inside its generic pharmacologic-class taxonomy dropdown, not a prose interaction statement. NCCIH's melatonin page does not mention spironolactone.

No documented interaction between Melatonin and Spironolactone was identified in the authoritative sources reviewed. This is not a guarantee that no interaction exists for every dose, formulation, or individual -- it means the sources checked did not document one.

Practical context

Both Melatonin's and Spironolactone's own current authoritative sources were checked directly, full text, in both directions; the taxonomy-list mention was deliberately not treated as a real interaction claim.

What the sources say

Spironolactone Tablets — FDA Prescribing Information — Sun Pharmaceutical Industries, Inc. (via DailyMed, U.S. National Library of Medicine)Melatonin: What You Need To Know — National Center for Complementary and Integrative Health (NIH)

Last reviewed 2026-08-23

Medical information disclaimer: this information is general and educational. It does not diagnose conditions, prescribe treatment, or determine whether a combination is safe for you personally. Follow your prescription label and ask a pharmacist or clinician before starting, stopping, or combining products. Full disclaimer.

Related guides

Related interactions