Can You Take Melatonin and Spironolactone Together?
No documented interaction was identified between melatonin and spironolactone in the sources reviewed.
What the interaction means
Spironolactone's FDA label's only "melatonin" hit is "MELATONIN RECEPTOR AGONIST" inside its generic pharmacologic-class taxonomy dropdown, not a prose interaction statement. NCCIH's melatonin page does not mention spironolactone.
No documented interaction was identified in the authoritative sources reviewed. This is not a guarantee that no interaction exists for every dose, formulation, or individual -- it means the sources checked did not document one.
Practical context
Both substances' own current authoritative sources were checked directly, full text, in both directions; the taxonomy-list mention was deliberately not treated as a real interaction claim.
What the sources say
Last reviewed 2026-08-23
Medical information disclaimer: this information is general and educational. It does not diagnose conditions, prescribe treatment, or determine whether a combination is safe for you personally. Follow your prescription label and ask a pharmacist or clinician before starting, stopping, or combining products. Full disclaimer.
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- Spironolactone and IronInsufficient evidence
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- Spironolactone and MagnesiumInsufficient evidence
- Spironolactone and CreatineInsufficient evidence
- Spironolactone and CaffeineInsufficient evidence
- Spironolactone and Vitamin KInsufficient evidence
- Spironolactone and LevothyroxineInsufficient evidence
- Spironolactone and TurmericInsufficient evidence
- Spironolactone and WarfarinInsufficient evidence
- Spironolactone and St. John's WortInsufficient evidence
- Spironolactone and CopperInsufficient evidence
- Spironolactone and SertralineInsufficient evidence
- Spironolactone and MetforminInsufficient evidence
- Spironolactone and ProbioticsInsufficient evidence
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- Spironolactone and ZincInsufficient evidence
- Spironolactone and DoxycyclineInsufficient evidence
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