Can You Take Copper and Spironolactone Together?
Copper's own NIH fact sheet states it is not known to interact with any medications, and no interaction with spironolactone is documented.
What the interaction means
The NIH Office of Dietary Supplements' copper fact sheet states plainly: "Copper is not known to interact with any medications." Spironolactone's FDA label's full Drug Interactions section does not mention copper.
No documented interaction was identified in the authoritative sources reviewed. This is not a guarantee that no interaction exists for every dose, formulation, or individual -- it means the sources checked did not document one.
Practical context
Copper's own source gives an explicit negative statement, which is why this is rated higher evidence quality.
What the sources say
Last reviewed 2026-08-23
Medical information disclaimer: this information is general and educational. It does not diagnose conditions, prescribe treatment, or determine whether a combination is safe for you personally. Follow your prescription label and ask a pharmacist or clinician before starting, stopping, or combining products. Full disclaimer.
Related interactions
- Copper and CiprofloxacinInsufficient evidence
- Copper and ZincMonitor
- Copper and TurmericInsufficient evidence
- Copper and IronInsufficient evidence
- Copper and MagnesiumInsufficient evidence
- Copper and WarfarinInsufficient evidence
- Copper and Vitamin B12Insufficient evidence
- Copper and PotassiumInsufficient evidence
- Copper and CalciumInsufficient evidence
- Copper and AtorvastatinInsufficient evidence
- Copper and Vitamin KInsufficient evidence
- Copper and CoQ10 (Coenzyme Q10)Insufficient evidence
- Copper and MetforminInsufficient evidence
- Copper and St. John's WortInsufficient evidence
- Copper and LevothyroxineInsufficient evidence
- Copper and LisinoprilInsufficient evidence
- Copper and OmeprazoleInsufficient evidence
- Copper and SertralineInsufficient evidence
- Copper and CreatineInsufficient evidence
- Copper and Vitamin DInsufficient evidence
- Copper and MelatoninInsufficient evidence
- Copper and ProbioticsInsufficient evidence
- Copper and CaffeineInsufficient evidence
- Copper and DoxycyclineInsufficient evidence
- Spironolactone and IronInsufficient evidence
- Spironolactone and PotassiumAvoid combining
- Spironolactone and CalciumInsufficient evidence
- Spironolactone and CoQ10 (Coenzyme Q10)Insufficient evidence
- Spironolactone and CiprofloxacinInsufficient evidence
- Spironolactone and MagnesiumInsufficient evidence
- Spironolactone and CreatineInsufficient evidence
- Spironolactone and CaffeineInsufficient evidence
- Spironolactone and Vitamin KInsufficient evidence
- Spironolactone and LevothyroxineInsufficient evidence
- Spironolactone and TurmericInsufficient evidence
- Spironolactone and WarfarinInsufficient evidence
- Spironolactone and St. John's WortInsufficient evidence
- Spironolactone and SertralineInsufficient evidence
- Spironolactone and MelatoninInsufficient evidence
- Spironolactone and MetforminInsufficient evidence
- Spironolactone and ProbioticsInsufficient evidence
- Spironolactone and Vitamin DInsufficient evidence
- Spironolactone and ZincInsufficient evidence
- Spironolactone and DoxycyclineInsufficient evidence
- Spironolactone and OmeprazoleInsufficient evidence
- Spironolactone and Vitamin B12Insufficient evidence
- Spironolactone and AtorvastatinInsufficient evidence
- Spironolactone and LisinoprilUse caution