Can You Take Copper and Spironolactone Together?
Copper's own NIH fact sheet states it is not known to interact with any medications, and no interaction with spironolactone is documented.
See the full Copper page and Spironolactone page for other reviewed interactions and reference information.
What the interaction means
The NIH Office of Dietary Supplements' copper fact sheet states plainly: "Copper is not known to interact with any medications." Spironolactone's FDA label's full Drug Interactions section does not mention copper.
No documented interaction between Copper and Spironolactone was identified in the authoritative sources reviewed. This is not a guarantee that no interaction exists for every dose, formulation, or individual -- it means the sources checked did not document one.
Practical context
Copper's own source gives an explicit negative statement, which is why this is rated higher evidence quality.
What the sources say
Last reviewed 2026-08-23
Medical information disclaimer: this information is general and educational. It does not diagnose conditions, prescribe treatment, or determine whether a combination is safe for you personally. Follow your prescription label and ask a pharmacist or clinician before starting, stopping, or combining products. Full disclaimer.
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- Spironolactone and LisinoprilUse caution
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- Spironolactone and Omega-3 / Fish OilInsufficient evidence
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- Spironolactone and AspirinMonitor
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