Can You Take Iron and Spironolactone Together?
No documented interaction was identified between iron and spironolactone in the sources reviewed.
See the full Iron page and Spironolactone page for other reviewed interactions and reference information.
What the interaction means
Spironolactone's FDA label names 13 drugs/classes (potassium-increasing agents, ACE inhibitors, ARBs, NSAIDs, heparin, lithium, digoxin, cholestyramine, aspirin, and others) -- iron is not among them. Iron's own NIH ODS fact sheet names levodopa, levothyroxine, lansoprazole/omeprazole, and calcium as its documented drug interactions -- spironolactone is not among them either.
No documented interaction between Iron and Spironolactone was identified in the authoritative sources reviewed. This is not a guarantee that no interaction exists for every dose, formulation, or individual -- it means the sources checked did not document one.
Practical context
Spironolactone's FDA label and iron's NIH ODS fact sheet were checked directly, full text, in both directions. Neither source names the other.
What the sources say
Last reviewed 2026-08-25
Medical information disclaimer: this information is general and educational. It does not diagnose conditions, prescribe treatment, or determine whether a combination is safe for you personally. Follow your prescription label and ask a pharmacist or clinician before starting, stopping, or combining products. Full disclaimer.
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