Can I Take These?

Can You Take Ciprofloxacin and Spironolactone Together?

No documented interaction was identified between ciprofloxacin and spironolactone in the sources reviewed.

No documented interaction identifiedEvidence: Moderate

What the interaction means

Spironolactone's FDA label's only mentions of ciprofloxacin's drug class ('QUINOLONE ANTIMICROBIAL', 'FLUOROQUINOLONE ANTIBACTERIAL') are inside its generic pharmacologic-class taxonomy dropdown, not a prose interaction statement. Ciprofloxacin's own label does not mention spironolactone.

No documented interaction was identified in the authoritative sources reviewed. This is not a guarantee that no interaction exists for every dose, formulation, or individual -- it means the sources checked did not document one.

Practical context

Both substances' own current FDA labels were checked directly, full text, in both directions; the taxonomy-list mentions were deliberately not treated as a real interaction claim.

What the sources say

Spironolactone Tablets — FDA Prescribing Information — Sun Pharmaceutical Industries, Inc. (via DailyMed, U.S. National Library of Medicine)Ciprofloxacin Tablet — FDA Prescribing Information — Rising Pharmaceuticals, Inc. (via DailyMed, U.S. National Library of Medicine)

Last reviewed 2026-08-23

Medical information disclaimer: this information is general and educational. It does not diagnose conditions, prescribe treatment, or determine whether a combination is safe for you personally. Follow your prescription label and ask a pharmacist or clinician before starting, stopping, or combining products. Full disclaimer.

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