Can I Take These?

Can You Take Ciprofloxacin and Spironolactone Together?

No documented interaction was identified between ciprofloxacin and spironolactone in the sources reviewed.

No documented interaction identifiedEvidence: Moderate

See the full Ciprofloxacin page and Spironolactone page for other reviewed interactions and reference information.

What the interaction means

Spironolactone's FDA label's only mentions of ciprofloxacin's drug class ('QUINOLONE ANTIMICROBIAL', 'FLUOROQUINOLONE ANTIBACTERIAL') are inside its generic pharmacologic-class taxonomy dropdown, not a prose interaction statement. Ciprofloxacin's own label does not mention spironolactone.

No documented interaction between Ciprofloxacin and Spironolactone was identified in the authoritative sources reviewed. This is not a guarantee that no interaction exists for every dose, formulation, or individual -- it means the sources checked did not document one.

Practical context

Both substances' own current FDA labels were checked directly, full text, in both directions; the taxonomy-list mentions were deliberately not treated as a real interaction claim.

What the sources say

Spironolactone Tablets — FDA Prescribing Information — Sun Pharmaceutical Industries, Inc. (via DailyMed, U.S. National Library of Medicine)Ciprofloxacin Tablet — FDA Prescribing Information — Rising Pharmaceuticals, Inc. (via DailyMed, U.S. National Library of Medicine)

Last reviewed 2026-08-23

Medical information disclaimer: this information is general and educational. It does not diagnose conditions, prescribe treatment, or determine whether a combination is safe for you personally. Follow your prescription label and ask a pharmacist or clinician before starting, stopping, or combining products. Full disclaimer.

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