Can I Take These?

Can You Take Ashwagandha and Spironolactone Together?

Ashwagandha is named by NCCIH as a supplement that may interact with high blood pressure medications; spironolactone is FDA-labeled as an add-on hypertension treatment.

MonitorEvidence: Moderate

See the full Ashwagandha page and Spironolactone page for other reviewed interactions and reference information.

What the interaction means

NCCIH's ashwagandha fact sheet states: "There is evidence that ashwagandha might interact with some medications, including those for diabetes and high blood pressure..." Spironolactone's own FDA label states: "Spironolactone tablets are indicated as add-on therapy for the treatment of hypertension, to lower blood pressure in patients who are not adequately controlled on other agents." NCCIH does not name spironolactone specifically or describe the mechanism beyond this class-level statement.

Why it may happen

Not further specified by NCCIH beyond classifying high blood pressure medications generally as a class ashwagandha might interact with.

Practical context

This is a class-level finding, not a spironolactone-specific one -- NCCIH does not give a spacing interval or dose-adjustment instruction. Anyone taking spironolactone who is considering ashwagandha should discuss it with their prescriber and monitor blood pressure for an additive lowering effect.

What the sources say

Spironolactone Tablets — FDA Prescribing Information — Sun Pharmaceutical Industries, Inc. (via DailyMed, U.S. National Library of Medicine)Ashwagandha — National Center for Complementary and Integrative Health (NIH)

Last reviewed 2026-08-24

Medical information disclaimer: this information is general and educational. It does not diagnose conditions, prescribe treatment, or determine whether a combination is safe for you personally. Follow your prescription label and ask a pharmacist or clinician before starting, stopping, or combining products. Full disclaimer.

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