Can I Take These?

Can You Take Ashwagandha and Melatonin Together?

No documented interaction was identified between ashwagandha and melatonin in the sources reviewed.

No documented interaction identifiedEvidence: Moderate

See the full Ashwagandha page and Melatonin page for other reviewed interactions and reference information.

What the interaction means

NCCIH's ashwagandha fact sheet names 'sedatives' as an interacting class, but its own supplement-interaction page clarifies this specifically means benzodiazepine/anti-anxiety drugs like Valium and Xanax -- not melatonin, a hormone supplement. NCCIH's melatonin page does not mention ashwagandha.

No documented interaction was identified in the authoritative sources reviewed. This is not a guarantee that no interaction exists for every dose, formulation, or individual -- it means the sources checked did not document one.

Practical context

Both substances' own current authoritative sources were checked directly, full text, in both directions; the 'sedatives' class was deliberately not extended to melatonin, since NCCIH's own clarifying page ties that class specifically to benzodiazepine/anti-anxiety drugs.

What the sources say

Some Supplements May Increase the Effects (and Side Effects) of Medications — National Center for Complementary and Integrative Health (NIH)Ashwagandha — National Center for Complementary and Integrative Health (NIH)Melatonin: What You Need To Know — National Center for Complementary and Integrative Health (NIH)

Last reviewed 2026-08-24

Medical information disclaimer: this information is general and educational. It does not diagnose conditions, prescribe treatment, or determine whether a combination is safe for you personally. Follow your prescription label and ask a pharmacist or clinician before starting, stopping, or combining products. Full disclaimer.

Related interactions