Can I Take These?

Can You Take Calcium and Melatonin Together?

No documented interaction was identified between calcium and melatonin in the sources reviewed.

No documented interaction identifiedEvidence: Moderate

See the full Calcium page and Melatonin page for other reviewed interactions and reference information.

What the interaction means

NCCIH's melatonin page names exactly two classes needing medical supervision -- epilepsy and blood thinner medications -- and calcium fits neither. Calcium's own NIH ODS fact sheet names dolutegravir, levothyroxine, lithium, and quinolone antibiotics as its documented drug interactions -- melatonin is not among them.

No documented interaction between Calcium and Melatonin was identified in the authoritative sources reviewed. This is not a guarantee that no interaction exists for every dose, formulation, or individual -- it means the sources checked did not document one.

Practical context

NCCIH's melatonin page and calcium's NIH ODS fact sheet were checked directly, full text, in both directions. Calcium is not an anticoagulant/antiplatelet drug or an epilepsy medication.

What the sources say

Calcium — Consumer — NIH Office of Dietary SupplementsMelatonin: What You Need To Know — National Center for Complementary and Integrative Health (NIH)

Last reviewed 2026-08-25

Medical information disclaimer: this information is general and educational. It does not diagnose conditions, prescribe treatment, or determine whether a combination is safe for you personally. Follow your prescription label and ask a pharmacist or clinician before starting, stopping, or combining products. Full disclaimer.

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