Can You Take Melatonin and St. John's Wort Together?
No documented interaction was identified between melatonin and St. John's Wort in the sources reviewed.
What the interaction means
NCCIH's St. John's Wort page does not mention melatonin. NCCIH's melatonin page does not mention St. John's Wort.
No documented interaction was identified in the authoritative sources reviewed. This is not a guarantee that no interaction exists for every dose, formulation, or individual -- it means the sources checked did not document one.
Practical context
Both substances' own current authoritative sources were checked directly, full text, in both directions.
What the sources say
Last reviewed 2026-08-23
Medical information disclaimer: this information is general and educational. It does not diagnose conditions, prescribe treatment, or determine whether a combination is safe for you personally. Follow your prescription label and ask a pharmacist or clinician before starting, stopping, or combining products. Full disclaimer.
Related interactions
- Melatonin and CoQ10 (Coenzyme Q10)Insufficient evidence
- Melatonin and OmeprazoleInsufficient evidence
- Melatonin and WarfarinInsufficient evidence
- Melatonin and AtorvastatinInsufficient evidence
- Melatonin and MagnesiumInsufficient evidence
- Melatonin and CalciumInsufficient evidence
- Melatonin and ProbioticsInsufficient evidence
- Melatonin and CiprofloxacinInsufficient evidence
- Melatonin and SertralineInsufficient evidence
- Melatonin and IronInsufficient evidence
- Melatonin and Vitamin B12Insufficient evidence
- Melatonin and PotassiumInsufficient evidence
- Melatonin and SpironolactoneInsufficient evidence
- Melatonin and ZincInsufficient evidence
- Melatonin and CopperInsufficient evidence
- Melatonin and LisinoprilInsufficient evidence
- Melatonin and DoxycyclineInsufficient evidence
- Melatonin and MetforminInsufficient evidence
- Melatonin and CreatineInsufficient evidence
- Melatonin and Vitamin DInsufficient evidence
- Melatonin and CaffeineInsufficient evidence
- Melatonin and TurmericInsufficient evidence
- Melatonin and Vitamin KInsufficient evidence
- Melatonin and LevothyroxineInsufficient evidence
- St. John's Wort and CiprofloxacinInsufficient evidence
- St. John's Wort and MagnesiumInsufficient evidence
- St. John's Wort and WarfarinUse caution
- St. John's Wort and CalciumInsufficient evidence
- St. John's Wort and IronInsufficient evidence
- St. John's Wort and SertralineUse caution
- St. John's Wort and Vitamin B12Insufficient evidence
- St. John's Wort and Vitamin KInsufficient evidence
- St. John's Wort and LevothyroxineInsufficient evidence
- St. John's Wort and PotassiumInsufficient evidence
- St. John's Wort and SpironolactoneInsufficient evidence
- St. John's Wort and AtorvastatinInsufficient evidence
- St. John's Wort and ZincInsufficient evidence
- St. John's Wort and CoQ10 (Coenzyme Q10)Insufficient evidence
- St. John's Wort and OmeprazoleInsufficient evidence
- St. John's Wort and MetforminInsufficient evidence
- St. John's Wort and LisinoprilInsufficient evidence
- St. John's Wort and DoxycyclineInsufficient evidence
- St. John's Wort and CopperInsufficient evidence
- St. John's Wort and CaffeineInsufficient evidence
- St. John's Wort and Vitamin DInsufficient evidence
- St. John's Wort and ProbioticsInsufficient evidence
- St. John's Wort and CreatineInsufficient evidence
- St. John's Wort and TurmericInsufficient evidence