Can You Take Magnesium and St. John's Wort Together?
No documented interaction was identified between magnesium and St. John's Wort in the sources reviewed.
See the full Magnesium page and St. John's Wort page for other reviewed interactions and reference information.
What the interaction means
NCCIH's St. John's Wort page names several drugs it can weaken (antidepressants, birth control, cyclosporine, anticonvulsants, heart medications, HIV drugs, cancer medications, warfarin, certain statins) -- magnesium is not among them. Magnesium's own NIH ODS fact sheet names bisphosphonates, certain antibiotics, diuretics, and acid reflux/peptic ulcer drugs as its documented drug interactions -- St. John's Wort is not among them either.
No documented interaction between Magnesium and St. John's Wort was identified in the authoritative sources reviewed. This is not a guarantee that no interaction exists for every dose, formulation, or individual -- it means the sources checked did not document one.
Practical context
NCCIH's St. John's Wort page and magnesium's NIH ODS fact sheet were checked directly, full text, in both directions. Neither source names the other.
What the sources say
Last reviewed 2026-08-25
Medical information disclaimer: this information is general and educational. It does not diagnose conditions, prescribe treatment, or determine whether a combination is safe for you personally. Follow your prescription label and ask a pharmacist or clinician before starting, stopping, or combining products. Full disclaimer.
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