Can You Take Metformin and St. John's Wort Together?

No documented interaction was identified between metformin and St. John's Wort in the sources reviewed.

No documented interaction identifiedEvidence: Moderate

See the full Metformin page and St. John's Wort page for other reviewed interactions and reference information.

What the interaction means

Metformin's FDA label does not mention St. John's Wort. NCCIH's St. John's Wort page does not mention metformin.

No documented interaction between Metformin and St. John's Wort was identified in the authoritative sources reviewed. This is not a guarantee that no interaction exists for every dose, formulation, or individual -- it means the sources checked did not document one.

Practical context

Both substances' own current authoritative sources were checked directly, in both directions.

What the sources say

Last reviewed 2026-08-23

Medical information disclaimer: this information is general and educational. It does not diagnose conditions, prescribe treatment, or determine whether a combination is safe for you personally. Follow your prescription label and ask a pharmacist or clinician before starting, stopping, or combining products. Full disclaimer.

Related guides

Related interactions