Can You Take Metformin and Vitamin D Together?
No documented interaction was identified between metformin and vitamin D in the sources reviewed.
See the full Metformin page and Vitamin D page for other reviewed interactions and reference information.
What the interaction means
Metformin's FDA label names ~19 drugs/classes affecting glycemic control or lactic-acidosis risk (carbonic anhydrase inhibitors, ranolazine, alcohol, diuretics, corticosteroids, and more) -- vitamin D is not among them. MedlinePlus's vitamin D page does not mention metformin.
No documented interaction between Metformin and Vitamin D was identified in the authoritative sources reviewed. This is not a guarantee that no interaction exists for every dose, formulation, or individual -- it means the sources checked did not document one.
Practical context
Metformin's FDA label and vitamin D's MedlinePlus page were checked directly, full text, in both directions. Vitamin D is not among metformin's named glycemic-control or clearance concerns.
What the sources say
Last reviewed 2026-08-25
Medical information disclaimer: this information is general and educational. It does not diagnose conditions, prescribe treatment, or determine whether a combination is safe for you personally. Follow your prescription label and ask a pharmacist or clinician before starting, stopping, or combining products. Full disclaimer.
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