Can I Take These?

Can You Take Metformin and Probiotics Together?

No documented interaction was identified between metformin and probiotics in the sources reviewed.

No documented interaction identifiedEvidence: Moderate

See the full Metformin page and Probiotics page for other reviewed interactions and reference information.

What the interaction means

Metformin's FDA label names ~19 drugs/classes affecting glycemic control or lactic-acidosis risk -- probiotics are not among them. NCCIH's probiotics page's only medication-related discussion anywhere is research on reducing antibiotic-associated diarrhea, and does not mention metformin.

No documented interaction between Metformin and Probiotics was identified in the authoritative sources reviewed. This is not a guarantee that no interaction exists for every dose, formulation, or individual -- it means the sources checked did not document one.

Practical context

Metformin's FDA label and NCCIH's probiotics page were checked directly, full text, in both directions. Metformin is not an antibiotic, so probiotics' one documented medication-related finding does not apply here.

What the sources say

Metformin Hydrochloride Tablets, USP — FDA Prescribing Information — Granules Pharmaceuticals Inc. (via DailyMed, U.S. National Library of Medicine)Probiotics: What You Need To Know — National Center for Complementary and Integrative Health (NIH)

Last reviewed 2026-08-25

Medical information disclaimer: this information is general and educational. It does not diagnose conditions, prescribe treatment, or determine whether a combination is safe for you personally. Follow your prescription label and ask a pharmacist or clinician before starting, stopping, or combining products. Full disclaimer.

Related interactions