Can I Take These?

Can You Take Omeprazole and Probiotics Together?

No documented interaction was identified between omeprazole and probiotics in the sources reviewed.

No documented interaction identifiedEvidence: Moderate

See the full Omeprazole page and Probiotics page for other reviewed interactions and reference information.

What the interaction means

Omeprazole's FDA label does not mention probiotics. NCCIH's probiotics page's only medication-related discussion anywhere is research on reducing antibiotic-associated diarrhea, and does not mention omeprazole.

No documented interaction between Omeprazole and Probiotics was identified in the authoritative sources reviewed. This is not a guarantee that no interaction exists for every dose, formulation, or individual -- it means the sources checked did not document one.

Practical context

Omeprazole's FDA label and NCCIH's probiotics page were checked directly, full text, in both directions. Omeprazole is not an antibiotic, so probiotics' one documented medication-related finding does not apply here.

What the sources say

Omeprazole Delayed-Release Capsules — FDA Prescribing Information — American Health Packaging (via DailyMed, U.S. National Library of Medicine)Probiotics: What You Need To Know — National Center for Complementary and Integrative Health (NIH)

Last reviewed 2026-08-25

Medical information disclaimer: this information is general and educational. It does not diagnose conditions, prescribe treatment, or determine whether a combination is safe for you personally. Follow your prescription label and ask a pharmacist or clinician before starting, stopping, or combining products. Full disclaimer.

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