Can I Take These?

Can You Take Escitalopram and Omeprazole Together?

No documented interaction was identified between escitalopram and omeprazole in the sources reviewed.

No documented interaction identifiedEvidence: Moderate

See the full Escitalopram page and Omeprazole page for other reviewed interactions and reference information.

What the interaction means

Omeprazole's FDA label has a dedicated Drug Interactions entry for citalopram, a related but distinct drug: "Clinical Impact: Increased exposure of citalopram leading to an increased risk of QT prolongation," with the instruction to "Limit the dose of citalopram to a maximum of 20 mg per day." The word 'escitalopram' does not appear anywhere in omeprazole's label. Escitalopram's own FDA label discusses CYP2C19 only as one of two enzymes involved in its own metabolism, without any omeprazole-specific or CYP2C19-inhibitor-specific dosing guidance.

No documented interaction was identified in the authoritative sources reviewed. This is not a guarantee that no interaction exists for every dose, formulation, or individual -- it means the sources checked did not document one.

Practical context

This is a case where a related drug (citalopram) has a clearly documented, name-specific interaction with omeprazole that does not extend to escitalopram on omeprazole's own label. Escitalopram is the single active enantiomer of citalopram and metabolized by the same enzyme (CYP2C19), so this absence of a named escitalopram-specific warning should not be read as a guarantee of no clinical significance -- but it is not what either label currently documents, and this file does not attribute the citalopram-specific finding to escitalopram.

What the sources say

Omeprazole Delayed-Release Capsules — FDA Prescribing Information — American Health Packaging (via DailyMed, U.S. National Library of Medicine)LEXAPRO (escitalopram) Tablets and Oral Solution — FDA Prescribing Information — Allergan, Inc. (via DailyMed, U.S. National Library of Medicine)

Last reviewed 2026-08-24

Medical information disclaimer: this information is general and educational. It does not diagnose conditions, prescribe treatment, or determine whether a combination is safe for you personally. Follow your prescription label and ask a pharmacist or clinician before starting, stopping, or combining products. Full disclaimer.

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