Escitalopram

Escitalopram is a prescription SSRI antidepressant used to treat major depressive disorder and generalized anxiety disorder.

Medication

What it is

Escitalopram (brand name Lexapro) is a selective serotonin reuptake inhibitor (SSRI) FDA-approved for the acute and maintenance treatment of major depressive disorder and the acute treatment of generalized anxiety disorder in adults. Per MedlinePlus, it 'works by increasing the amount of serotonin, a natural substance in the brain that helps maintain mental balance.' Its FDA prescribing information documents drug interactions involving monoamine oxidase inhibitors (contraindicated, serotonin syndrome risk), other serotonergic drugs (including other SSRIs, SNRIs, triptans, tricyclic antidepressants, lithium, tramadol, tryptophan, buspirone, amphetamines, and St. John's Wort), pimozide (contraindicated), and drugs that interfere with hemostasis (aspirin, NSAIDs, warfarin, and other anticoagulants, which may add to bleeding risk). Escitalopram is metabolized in part by CYP3A4 and CYP2C19. Escitalopram is the single active (S)-enantiomer of the related but distinct drug citalopram; this file treats the two as separate substances and does not attribute citalopram-specific label findings to escitalopram unless escitalopram is named directly.

How it is commonly taken

Typically taken once daily, in the morning or evening, with or without food, for major depressive disorder or generalized anxiety disorder.

Known interaction categories

  • Use caution
  • Insufficient evidence

Published interaction pages on this site

Related guides

Sources

Last reviewed 2026-08-24

Medical information disclaimer: this information is general and educational. It does not diagnose conditions, prescribe treatment, or determine whether a combination is safe for you personally. Follow your prescription label and ask a pharmacist or clinician before starting, stopping, or combining products. Full disclaimer.