Can I Take These?

Can You Take Aspirin and Escitalopram Together?

Escitalopram's FDA label names aspirin directly as adding to a documented bleeding-risk warning.

Use cautionEvidence: High

See the full Aspirin page and Escitalopram page for other reviewed interactions and reference information.

What the interaction means

Escitalopram's FDA prescribing information, Section 5.7, "Increased Risk of Bleeding," states: "Drugs that interfere with serotonin reuptake inhibition, including escitalopram, increase the risk of bleeding events. Concomitant use of aspirin, nonsteroidal antiinflammatory drugs (NSAIDs), other antiplatelet drugs, warfarin, and other anticoagulants may add to the risk." Escitalopram's MedlinePlus page separately names aspirin directly: "the following nonprescription or herbal products may interact with escitalopram: aspirin, ibuprofen (Advil®, Motrin® IB), naproxen (Aleve®), St. John's wort, or tryptophan."

Why it may happen

SSRIs like escitalopram reduce platelets' ability to take up serotonin, which impairs platelet aggregation; combined with aspirin's own antiplatelet, COX-1-inhibiting effect, the two mechanisms add to overall bleeding risk.

Practical context

Anyone taking escitalopram who also uses aspirin regularly, including low-dose cardioprotective aspirin, should be aware of this bleeding-risk warning named directly on escitalopram's FDA label and discuss it with their prescriber, watching for unusual bruising or bleeding.

What the sources say

Escitalopram — MedlinePlus, U.S. National Library of MedicineEscitalopram Oxalate Tablets — FDA Prescribing Information — Legacy Pharmaceutical Packaging, LLC / Cipla Ltd. (via DailyMed, U.S. National Library of Medicine)

Last reviewed 2026-08-24

Medical information disclaimer: this information is general and educational. It does not diagnose conditions, prescribe treatment, or determine whether a combination is safe for you personally. Follow your prescription label and ask a pharmacist or clinician before starting, stopping, or combining products. Full disclaimer.

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