Can I Take These?

Can You Take Escitalopram and Levothyroxine Together?

No documented interaction was identified between escitalopram and levothyroxine in the sources reviewed.

No documented interaction identifiedEvidence: Moderate

See the full Escitalopram page and Levothyroxine page for other reviewed interactions and reference information.

What the interaction means

Levothyroxine's FDA label, Section 7.5, states: "Concurrent use of tricyclic (e.g., Amitriptyline) or tetracyclic (e.g., Maprotiline) antidepressants and levothyroxine sodium capsules may increase the therapeutic and toxic effects of both drugs." This names a different antidepressant class (tricyclics/tetracyclics) than escitalopram's SSRI class; the words 'escitalopram,' 'citalopram,' 'SSRI,' and 'serotonin' do not appear anywhere in levothyroxine's label. Escitalopram's own FDA label does not mention levothyroxine or thyroid hormone.

No documented interaction was identified in the authoritative sources reviewed. This is not a guarantee that no interaction exists for every dose, formulation, or individual -- it means the sources checked did not document one.

Practical context

Both substances' own current authoritative sources were checked directly, full text, in both directions. The label's tricyclic/tetracyclic-specific entry does not extend to escitalopram by name or by its own SSRI class, so this is documented as no interaction found, with that nuance noted transparently.

What the sources say

Levothyroxine Sodium Capsules — FDA Prescribing Information — YARAL Pharma, Inc. (via DailyMed, U.S. National Library of Medicine)LEXAPRO (escitalopram) Tablets and Oral Solution — FDA Prescribing Information — Allergan, Inc. (via DailyMed, U.S. National Library of Medicine)

Last reviewed 2026-08-24

Medical information disclaimer: this information is general and educational. It does not diagnose conditions, prescribe treatment, or determine whether a combination is safe for you personally. Follow your prescription label and ask a pharmacist or clinician before starting, stopping, or combining products. Full disclaimer.

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