Can I Take These?

Can You Take Levothyroxine and Sertraline Together?

Starting sertraline can increase how much levothyroxine you need -- named directly on levothyroxine's FDA label.

MonitorEvidence: High

What the interaction means

Levothyroxine's FDA label states, in its Antidepressant Therapy section: "Administration of sertraline in patients stabilized on levothyroxine sodium capsules may result in increased levothyroxine sodium capsules requirements." This is a distinct, specifically-named finding about sertraline within a section that also separately discusses tricyclic/tetracyclic antidepressants.

Why it may happen

Not further specified by the label beyond stating the effect on levothyroxine dose requirements.

Practical context

Patients stabilized on a levothyroxine dose who start sertraline may need their thyroid function/dose reassessed. No specific spacing interval applies -- this is a dose-requirement effect over time, not a same-day absorption-timing issue.

What the sources say

Levothyroxine Sodium Capsules — FDA Prescribing Information — YARAL Pharma, Inc. (via DailyMed, U.S. National Library of Medicine)

Last reviewed 2026-08-23

Medical information disclaimer: this information is general and educational. It does not diagnose conditions, prescribe treatment, or determine whether a combination is safe for you personally. Follow your prescription label and ask a pharmacist or clinician before starting, stopping, or combining products. Full disclaimer.

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