Can I Take These?

Can You Take Sertraline and Spironolactone Together?

No documented interaction was identified between spironolactone and sertraline in the sources reviewed.

No documented interaction identifiedEvidence: Moderate

See the full Sertraline page and Spironolactone page for other reviewed interactions and reference information.

What the interaction means

Spironolactone's FDA label does not mention sertraline. Sertraline's own FDA label does not mention spironolactone.

No documented interaction between Sertraline and Spironolactone was identified in the authoritative sources reviewed. This is not a guarantee that no interaction exists for every dose, formulation, or individual -- it means the sources checked did not document one.

Practical context

Both Sertraline's and Spironolactone's own current FDA labels were checked directly, full text, in both directions.

What the sources say

Sertraline Hydrochloride Tablets — FDA Prescribing Information — Via DailyMed, U.S. National Library of MedicineSpironolactone Tablets — FDA Prescribing Information — Sun Pharmaceutical Industries, Inc. (via DailyMed, U.S. National Library of Medicine)

Last reviewed 2026-08-23

Medical information disclaimer: this information is general and educational. It does not diagnose conditions, prescribe treatment, or determine whether a combination is safe for you personally. Follow your prescription label and ask a pharmacist or clinician before starting, stopping, or combining products. Full disclaimer.

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