Can I Take These?

Can You Take Losartan and Spironolactone Together?

Spironolactone's FDA label names angiotensin receptor blockers -- the drug class losartan belongs to -- as a specific risk factor for combined high potassium levels.

Use cautionEvidence: High

See the full Losartan page and Spironolactone page for other reviewed interactions and reference information.

What the interaction means

Spironolactone's FDA prescribing information states in its drug interactions section: "Examples of drugs that can increase potassium include: ACE inhibitors, angiotensin receptor blockers, non-steroidal anti-inflammatory drugs..." Its hyperkalemia warning states: "This risk is increased by impaired renal function or concomitant potassium supplementation, potassium-containing salt substitutes or drugs that increase potassium, such as angiotensin converting enzyme inhibitors and angiotensin receptor blockers." A separate warning adds: "Excessive diuresis may cause symptomatic dehydration, hypotension and worsening renal function, particularly in salt-depleted patients or those taking angiotensin converting enzyme inhibitors and angiotensin II receptor blockers." Losartan's own FDA label confirms it is an angiotensin II receptor blocker (ARB), and separately states that coadministering losartan with other drugs that raise serum potassium may result in hyperkalemia.

Why it may happen

Spironolactone is a potassium-sparing diuretic that causes the kidneys to retain potassium; losartan, as an ARB, reduces aldosterone through a related but distinct mechanism that also tends to raise potassium. Combining the two compounds this hyperkalemia risk.

Practical context

Unlike the Lisinopril + Losartan pair, spironolactone's label does not describe a named clinical trial of this specific combination -- the finding here rests on the ARB drug class being explicitly named (not losartan by name) alongside losartan's own label confirming its ARB classification. This is a real, class-level, cross-corroborated finding rather than a directly-named-drug finding, reflected here as 'caution' rather than 'avoid.'

What the sources say

Spironolactone Tablets — FDA Prescribing Information — Sun Pharmaceutical Industries, Inc. (via DailyMed, U.S. National Library of Medicine)Losartan Potassium Tablets — FDA Prescribing Information — Bryant Ranch Prepack (via DailyMed, U.S. National Library of Medicine)

Last reviewed 2026-08-24

Medical information disclaimer: this information is general and educational. It does not diagnose conditions, prescribe treatment, or determine whether a combination is safe for you personally. Follow your prescription label and ask a pharmacist or clinician before starting, stopping, or combining products. Full disclaimer.

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