Can You Take Creatine and Spironolactone Together?
No documented interaction was identified between creatine and spironolactone in the sources reviewed.
See the full Creatine page and Spironolactone page for other reviewed interactions and reference information.
What the interaction means
NCCIH's bodybuilding-supplements page (which covers creatine) does not mention spironolactone. Spironolactone's own FDA label does not mention creatine.
No documented interaction between Creatine and Spironolactone was identified in the authoritative sources reviewed. This is not a guarantee that no interaction exists for every dose, formulation, or individual -- it means the sources checked did not document one.
Practical context
Both Creatine's and Spironolactone's own current authoritative sources were checked directly, full text, in both directions.
What the sources say
Last reviewed 2026-08-23
Medical information disclaimer: this information is general and educational. It does not diagnose conditions, prescribe treatment, or determine whether a combination is safe for you personally. Follow your prescription label and ask a pharmacist or clinician before starting, stopping, or combining products. Full disclaimer.
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- Spironolactone and PotassiumAvoid combining
- Spironolactone and CalciumInsufficient evidence
- Spironolactone and CoQ10 (Coenzyme Q10)Insufficient evidence
- Spironolactone and CiprofloxacinInsufficient evidence
- Spironolactone and MagnesiumInsufficient evidence
- Spironolactone and Vitamin EInsufficient evidence
- Spironolactone and CaffeineInsufficient evidence
- Spironolactone and Vitamin KInsufficient evidence
- Spironolactone and TurmericInsufficient evidence
- Spironolactone and WarfarinInsufficient evidence
- Spironolactone and St. John's WortInsufficient evidence
- Spironolactone and CopperInsufficient evidence
- Spironolactone and SertralineInsufficient evidence
- Spironolactone and MelatoninInsufficient evidence
- Spironolactone and MetforminInsufficient evidence
- Spironolactone and Vitamin DInsufficient evidence
- Spironolactone and DoxycyclineInsufficient evidence
- Spironolactone and OmeprazoleInsufficient evidence
- Spironolactone and Vitamin B12Insufficient evidence
- Spironolactone and IronInsufficient evidence
- Spironolactone and AtorvastatinInsufficient evidence
- Spironolactone and LisinoprilUse caution
- Spironolactone and ZincInsufficient evidence
- Spironolactone and Omega-3 / Fish OilInsufficient evidence
- Spironolactone and AshwagandhaMonitor
- Spironolactone and ProbioticsInsufficient evidence
- Spironolactone and AspirinMonitor
- Spironolactone and Vitamin CInsufficient evidence
- Spironolactone and LevothyroxineInsufficient evidence
- Spironolactone and AmlodipineInsufficient evidence
- Spironolactone and EscitalopramInsufficient evidence
- Spironolactone and Folate / Folic AcidInsufficient evidence
- Spironolactone and IbuprofenUse caution
- Spironolactone and LosartanUse caution