Can I Take These?

Can You Take Creatine and Vitamin B12 Together?

No documented interaction was identified between vitamin B12 and creatine in the sources reviewed.

No documented interaction identifiedEvidence: Moderate

What the interaction means

NCCIH's bodybuilding-supplements page (which covers creatine) mentions vitamin B12 only as a generic dietary-supplement example in unrelated nutrition advice, not a creatine-specific interaction claim. The NIH ODS vitamin B12 fact sheet's interactions section names only gastric acid inhibitors and metformin -- creatine is not named.

No documented interaction was identified in the authoritative sources reviewed. This is not a guarantee that no interaction exists for every dose, formulation, or individual -- it means the sources checked did not document one.

Practical context

Both substances' own current authoritative sources were checked directly; the generic dietary-advice mention was deliberately not treated as a real interaction claim.

What the sources say

Vitamin B12 — Consumer — NIH Office of Dietary SupplementsBodybuilding and Performance Enhancement Supplements — National Center for Complementary and Integrative Health (NIH)

Last reviewed 2026-08-23

Medical information disclaimer: this information is general and educational. It does not diagnose conditions, prescribe treatment, or determine whether a combination is safe for you personally. Follow your prescription label and ask a pharmacist or clinician before starting, stopping, or combining products. Full disclaimer.

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