Can I Take These?

Can You Take Doxycycline and Vitamin B12 Together?

No documented interaction was identified between doxycycline and vitamin B12 in the sources reviewed.

No documented interaction identifiedEvidence: Moderate

What the interaction means

Doxycycline's FDA label's documented interactions are mineral-chelation-focused (calcium, magnesium, iron, aluminum, bismuth subsalicylate) -- vitamin B12 is not among them. Vitamin B12's own fact sheet does not mention doxycycline.

No documented interaction was identified in the authoritative sources reviewed. This is not a guarantee that no interaction exists for every dose, formulation, or individual -- it means the sources checked did not document one.

Practical context

Both substances' own current authoritative sources were checked directly, full text, in both directions.

What the sources say

Doxycycline Hyclate — FDA Prescribing Information — Sun Pharmaceutical Industries, Inc. (via DailyMed, U.S. National Library of Medicine)Vitamin B12 — Consumer — NIH Office of Dietary Supplements

Last reviewed 2026-08-23

Medical information disclaimer: this information is general and educational. It does not diagnose conditions, prescribe treatment, or determine whether a combination is safe for you personally. Follow your prescription label and ask a pharmacist or clinician before starting, stopping, or combining products. Full disclaimer.

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