Can I Take These?

Can You Take Doxycycline and Vitamin B12 Together?

No documented interaction was identified between doxycycline and vitamin B12 in the sources reviewed.

No documented interaction identifiedEvidence: Moderate

See the full Doxycycline page and Vitamin B12 page for other reviewed interactions and reference information.

What the interaction means

Doxycycline's FDA label's documented interactions are mineral-chelation-focused (calcium, magnesium, iron, aluminum, bismuth subsalicylate) -- vitamin B12 is not among them. Vitamin B12's own fact sheet does not mention doxycycline.

No documented interaction between Doxycycline and Vitamin B12 was identified in the authoritative sources reviewed. This is not a guarantee that no interaction exists for every dose, formulation, or individual -- it means the sources checked did not document one.

Practical context

Both Doxycycline's and Vitamin B12's own current authoritative sources were checked directly, full text, in both directions.

What the sources say

Doxycycline Hyclate — FDA Prescribing Information — Sun Pharmaceutical Industries, Inc. (via DailyMed, U.S. National Library of Medicine)Vitamin B12 — Consumer — NIH Office of Dietary Supplements

Last reviewed 2026-08-23

Medical information disclaimer: this information is general and educational. It does not diagnose conditions, prescribe treatment, or determine whether a combination is safe for you personally. Follow your prescription label and ask a pharmacist or clinician before starting, stopping, or combining products. Full disclaimer.

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