Can I Take These?

Can You Take Melatonin and Vitamin B12 Together?

No documented interaction was identified between melatonin and vitamin B12 in the sources reviewed.

No documented interaction identifiedEvidence: Moderate

See the full Melatonin page and Vitamin B12 page for other reviewed interactions and reference information.

What the interaction means

NCCIH's melatonin page names exactly two classes needing medical supervision -- epilepsy and blood thinner medications -- and vitamin B12 fits neither. The NIH ODS vitamin B12 fact sheet's interactions section names only gastric acid inhibitors and metformin -- melatonin is not among them.

No documented interaction between Melatonin and Vitamin B12 was identified in the authoritative sources reviewed. This is not a guarantee that no interaction exists for every dose, formulation, or individual -- it means the sources checked did not document one.

Practical context

NCCIH's melatonin page and vitamin B12's NIH ODS fact sheet were checked directly, full text, in both directions. Vitamin B12 is not an anticoagulant/antiplatelet drug or an epilepsy medication.

What the sources say

Vitamin B12 — Consumer — NIH Office of Dietary SupplementsMelatonin: What You Need To Know — National Center for Complementary and Integrative Health (NIH)

Last reviewed 2026-08-25

Medical information disclaimer: this information is general and educational. It does not diagnose conditions, prescribe treatment, or determine whether a combination is safe for you personally. Follow your prescription label and ask a pharmacist or clinician before starting, stopping, or combining products. Full disclaimer.

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