Can I Take These?

Can You Take Levothyroxine and Vitamin B12 Together?

No documented interaction was identified between vitamin B12 and levothyroxine in the sources reviewed.

No documented interaction identifiedEvidence: Moderate

What the interaction means

Levothyroxine's FDA label's only "vitamin B12" hit is inside its generic pharmacologic-class taxonomy dropdown list, not a prose interaction statement. The NIH ODS vitamin B12 fact sheet's interactions section names only gastric acid inhibitors and metformin -- levothyroxine is not named.

No documented interaction was identified in the authoritative sources reviewed. This is not a guarantee that no interaction exists for every dose, formulation, or individual -- it means the sources checked did not document one.

Practical context

Both substances' own current authoritative sources were checked directly; the taxonomy-list mention was deliberately not treated as a real interaction claim.

What the sources say

Vitamin B12 — Consumer — NIH Office of Dietary SupplementsLevothyroxine Sodium Capsules — FDA Prescribing Information — YARAL Pharma, Inc. (via DailyMed, U.S. National Library of Medicine)

Last reviewed 2026-08-23

Medical information disclaimer: this information is general and educational. It does not diagnose conditions, prescribe treatment, or determine whether a combination is safe for you personally. Follow your prescription label and ask a pharmacist or clinician before starting, stopping, or combining products. Full disclaimer.

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