Can I Take These?

Can You Take Ibuprofen and Levothyroxine Together?

No documented interaction was identified between ibuprofen and levothyroxine in the sources reviewed.

No documented interaction identifiedEvidence: Moderate

See the full Ibuprofen page and Levothyroxine page for other reviewed interactions and reference information.

What the interaction means

Levothyroxine's FDA label lists "Non-Steroidal Anti-inflammatory Drugs -- Fenamates" in its Table 3 of drugs that may alter thyroid hormone serum transport, but fenamates (e.g., mefenamic acid) are a distinct NSAID subclass from ibuprofen, which is a propionic-acid-derivative NSAID; the word 'ibuprofen' does not appear anywhere in the label, and no broader NSAID-class entry is present. Ibuprofen's own FDA label does not mention levothyroxine or thyroid hormone.

No documented interaction was identified in the authoritative sources reviewed. This is not a guarantee that no interaction exists for every dose, formulation, or individual -- it means the sources checked did not document one.

Practical context

Both substances' own current authoritative sources were checked directly, full text, in both directions. The label's fenamates-specific entry does not extend to ibuprofen by name or by its own NSAID subclass, so this is documented as no interaction found, with that nuance noted transparently.

What the sources say

Ibuprofen Tablets, USP — FDA Prescribing Information — Ascend Laboratories, LLC (via DailyMed, U.S. National Library of Medicine)Levothyroxine Sodium Capsules — FDA Prescribing Information — YARAL Pharma, Inc. (via DailyMed, U.S. National Library of Medicine)

Last reviewed 2026-08-24

Medical information disclaimer: this information is general and educational. It does not diagnose conditions, prescribe treatment, or determine whether a combination is safe for you personally. Follow your prescription label and ask a pharmacist or clinician before starting, stopping, or combining products. Full disclaimer.

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