Can I Take These?

Can You Take Ibuprofen and Losartan Together?

Losartan's FDA label names losartan directly in its NSAID drug-interaction section, warning of reduced kidney function and blunted blood-pressure control.

MonitorEvidence: High

See the full Ibuprofen page and Losartan page for other reviewed interactions and reference information.

What the interaction means

Losartan's FDA prescribing information, Section 7.3, "Non-Steroidal Anti-inflammatory Drugs (NSAIDS) Including Selective Cyclooxygenase-2 Inhibitors (COX-2 Inhibitors)," states: "In patients who are elderly, volume-depleted (including those on diuretic therapy), or with compromised renal function, coadministration of NSAIDs, including selective COX-2 inhibitors, with angiotensin II receptor antagonists (including losartan) may result in deterioration of renal function, including possible acute renal failure... The antihypertensive effect of angiotensin II receptor antagonists, including losartan, may be attenuated by NSAIDs." Losartan's MedlinePlus consumer page separately names ibuprofen directly: "the following nonprescription products may interact with losartan: aspirin and nonsteroidal anti-inflammatory drugs (NSAIDS) such as ibuprofen (Advil, Motrin, others) and naproxen (Aleve)."

Why it may happen

NSAIDs like ibuprofen inhibit renal prostaglandin synthesis, which can reduce glomerular filtration and blunt the blood-pressure-lowering effect of angiotensin receptor blockers like losartan, particularly in patients who are elderly, volume-depleted, or have compromised renal function.

Practical context

This is most relevant to regular or higher-dose ibuprofen use rather than a single occasional dose, and especially relevant in elderly patients, those with reduced kidney function, or those also on diuretics. Anyone on losartan who needs ibuprofen regularly should discuss it with the prescriber managing their blood pressure.

What the sources say

Losartan Potassium Tablets — FDA Prescribing Information — Granules Pharmaceuticals, Inc. (via DailyMed, U.S. National Library of Medicine)Losartan — MedlinePlus, U.S. National Library of Medicine

Last reviewed 2026-08-24

Medical information disclaimer: this information is general and educational. It does not diagnose conditions, prescribe treatment, or determine whether a combination is safe for you personally. Follow your prescription label and ask a pharmacist or clinician before starting, stopping, or combining products. Full disclaimer.

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