Can I Take These?

Can You Take Lisinopril and Losartan Together?

Lisinopril's FDA label names losartan directly, describing a clinical trial in which combining the two increased hyperkalemia and kidney injury, and instructs to avoid combining RAS-acting drugs in general.

Avoid combiningEvidence: High

See the full Lisinopril page and Losartan page for other reviewed interactions and reference information.

What the interaction means

Lisinopril's FDA prescribing information states in its "Dual Blockade of the Renin-Angiotensin System (RAS)" subsection: "The VA NEPHRON trial enrolled 1448 patients with type 2 diabetes, elevated urinary-albumin-to-creatinine ratio, and decreased estimated glomerular filtration rate... randomized them to lisinopril or placebo on a background of losartan therapy... Patients receiving the combination of losartan and lisinopril did not obtain any additional benefit compared to monotherapy for the combined endpoint of decline in GFR, end state renal disease, or death, but experienced an increased incidence of hyperkalemia and acute kidney injury compared with the monotherapy group." The same section states: "In general, avoid combined use of RAS inhibitors. Closely monitor blood pressure, renal function and electrolytes in patients on lisinopril and other agents that affect the RAS." Losartan's own label contains the matching general statement: "Dual blockade of the RAS with angiotensin receptor blockers, ACE inhibitors, or aliskiren is associated with increased risks of hypotension, syncope, hyperkalemia, and changes in renal function (including acute renal failure) compared to monotherapy."

Why it may happen

Losartan (an ARB) blocks angiotensin II receptors and lisinopril (an ACE inhibitor) blocks the enzyme that produces angiotensin II -- both act on the same renin-angiotensin system (RAS) pathway from different points. Combining them ("dual RAS blockade") does not reliably add blood-pressure or kidney-protective benefit over either drug alone, but does add risk of hyperkalemia, hypotension, and kidney injury.

Practical context

This is one of the more directly documented pairs in this dataset: a named clinical trial testing this exact combination is cited on lisinopril's own FDA label, alongside explicit 'avoid combined use' language. Someone already taking one of these two medications should not add the other without their prescriber's involvement.

What the sources say

Lisinopril Tablets — FDA Prescribing Information — Prinston Pharmaceutical Inc. (via DailyMed, U.S. National Library of Medicine)Losartan Potassium Tablets — FDA Prescribing Information — Bryant Ranch Prepack (via DailyMed, U.S. National Library of Medicine)

Last reviewed 2026-08-24

Medical information disclaimer: this information is general and educational. It does not diagnose conditions, prescribe treatment, or determine whether a combination is safe for you personally. Follow your prescription label and ask a pharmacist or clinician before starting, stopping, or combining products. Full disclaimer.

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