Can I Take These?

Can You Take Aspirin and Lisinopril Together?

Aspirin's own FDA label names RAS inhibitors, the drug class that includes lisinopril, as a documented interaction affecting kidney function and blood pressure control.

MonitorEvidence: Moderate

See the full Aspirin page and Lisinopril page for other reviewed interactions and reference information.

What the interaction means

Aspirin's DURLAZA label states: "Renin-angiotensin system (RAS) inhibitors: In patients who are elderly, volume-depleted (including those on diuretic therapy), or who have compromised renal function, coadministration of NSAIDs, including DURLAZA, with RAS inhibitors may result in deterioration of renal function, including possible acute renal failure... NSAIDs, including DURLAZA may attenuate the antihypertensive effects of RAS inhibitors." Lisinopril's own FDA label corroborates this with near-identical language in its own NSAID subsection.

Why it may happen

NSAIDs, including aspirin, inhibit renal prostaglandin synthesis, which can reduce glomerular filtration and blunt the blood-pressure-lowering effect of ACE inhibitors like lisinopril, particularly in patients who are elderly, volume-depleted, or have compromised renal function.

Practical context

Aspirin's label notes these effects are 'usually reversible' and recommends monitoring renal function periodically in patients receiving both an RAS inhibitor and aspirin. This is most relevant to regular or anti-inflammatory-dose aspirin use rather than occasional low-dose use, and especially relevant in elderly patients or those with reduced kidney function or on diuretics as well.

What the sources say

Lisinopril Tablets — FDA Prescribing Information — Prinston Pharmaceutical Inc. (via DailyMed, U.S. National Library of Medicine)DURLAZA (Aspirin) Extended-Release Capsules — FDA Prescribing Information — New Haven Pharmaceuticals, Inc. (via DailyMed, U.S. National Library of Medicine)

Last reviewed 2026-08-24

Medical information disclaimer: this information is general and educational. It does not diagnose conditions, prescribe treatment, or determine whether a combination is safe for you personally. Follow your prescription label and ask a pharmacist or clinician before starting, stopping, or combining products. Full disclaimer.

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