Can I Take These?

Can You Take Aspirin and Sertraline Together?

Aspirin is named directly on sertraline's FDA label as increasing bleeding risk when combined.

Use cautionEvidence: High

See the full Aspirin page and Sertraline page for other reviewed interactions and reference information.

What the interaction means

Sertraline's FDA prescribing information states in Section 5.3, "Increased Risk of Bleeding": "Concomitant use of aspirin, nonsteroidal anti-inflammatory drugs (NSAIDs), other antiplatelet drugs, warfarin, and other anticoagulants may add to this risk." Section 7.1, "Clinically Significant Drug Interactions," lists aspirin by name among drugs that interfere with hemostasis, alongside clopidogrel, heparin, and warfarin, and instructs informing patients of the increased bleeding risk.

Why it may happen

Sertraline, an SSRI, reduces platelets' ability to take up serotonin, which impairs platelet aggregation; combined with aspirin's own antiplatelet effect, the two mechanisms add to overall bleeding risk.

Practical context

Anyone taking sertraline who also uses aspirin regularly, including low-dose cardioprotective aspirin, should be aware of the additive bleeding-risk warning on sertraline's label and discuss it with their prescriber, watching for unusual bruising or bleeding.

What the sources say

Sertraline Hydrochloride Tablets — FDA Prescribing Information — Via DailyMed, U.S. National Library of MedicineDURLAZA (Aspirin) Extended-Release Capsules — FDA Prescribing Information — New Haven Pharmaceuticals, Inc. (via DailyMed, U.S. National Library of Medicine)

Last reviewed 2026-08-24

Medical information disclaimer: this information is general and educational. It does not diagnose conditions, prescribe treatment, or determine whether a combination is safe for you personally. Follow your prescription label and ask a pharmacist or clinician before starting, stopping, or combining products. Full disclaimer.

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